Dual Roles of Lactate in EGFR-TKI-Resistant Lung Cancer by Targeting GPR81 and MCT1

<div>GPR81 and MCT1 in patients of NSCLC. (a) Representative immunostaining of GPR81 and MCT1 expression in sensitive tissues (left) and insensitive tissues (right). Magnification, ×100 (upper), and ×400 (below). (b) The proportion of low/high GPR81 and MCT1 in TKI sensitive (<i>n</i> = 20) or resistance (<i>n</i> = 10) patients. <i>L</i>: low; <i>H</i>: high.</div>

Journal of Oncology

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Figure 4

Figure 4: Dual Roles of Lactate in EGFR-TKI-Resistant Lung Cancer by Targeting GPR81 and MCT1 