IL-2 Modulates TAMs Derived Exosomal MiRNAs to Ameliorate Hepatocellular Carcinoma Development and Progression

<div>The effects of the exosomes on HCC metastasis <i>in vivo</i>. (a) Representative images of H&amp;E-stained sections of metastatic nodules in liver and lung. (b) Percentage of mice with metastasis indicated from mice in Con, Exo<sup>TAM</sup>, and Exo<sup>IL2-TAM</sup> groups (<i>n</i> = 12 per group). (c) Representative images of IHC staining for Vimentin in the tumors. (d–h) Western blot analysis of MMP2, MMP9, N-cadherin, and E-cadherin proteins expression. 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Journal of Oncology

fig5

Figure 5

Figure 5: IL-2 Modulates TAMs Derived Exosomal MiRNAs to Ameliorate Hepatocellular Carcinoma Development and Progression 