β-Elemene Restrains PTEN mRNA Degradation to Restrain the Growth of Lung Cancer Cells via METTL3-Mediated N⁶ Methyladenosine Modification

Figure 4

Overexpression of METTL3 abrogated the regulatory role of β-elemene in lung cancer progression. (a) qRT-PCR detection results for the transfection efficiency of METTL3. (b) The efficacy of METTL3 overexpression was verified by RT-qPCR analysis. (c) CCK-8 assay was applied to detect the viability of A549 together with H1299 cells after different administrations. (d) The role of β-elemene/METTL3 in lung cancer cell apoptosis was evaluated by flow cytometry. (e) The quantitation of flow cytometry outcomes. Experimental data were represented as mean ± SD, and all assays were repeated thrice.

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