Research Article
β-Elemene Restrains PTEN mRNA Degradation to Restrain the Growth of Lung Cancer Cells via METTL3-Mediated N6 Methyladenosine Modification
Figure 6
β-Elemene enhanced PTEN expression through restraining METTL3-mediated m6A modification. (a) The detection outcomes of the total m6A level in A549 and H1299 cells administrated with β-elemene. (b, d) The RT-qPCR assay was adopted to examine PTEN in A549 together with H1299 cells following different administrations. (e, f) The impacts of β-elemene and METTL3 on the m6A modification of PTEN mRNA were estimated with the MeRIP-PCR assay. The experimental data were represented as mean ± SD, and all assays were repeated thrice.
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