MAP9 Exhibits Protumor Activities and Immune Escape toward Bladder Cancer by Mediating TGF-<i>β</i>1 Pathway

<div>MAP9 regulated cell cycle-related genes and epithelial mesenchymal transition (EMT) via the transforming growth factor beta 1 (TGF-<i>β</i>1) pathway. (a) The messenger ribonucleic acid (mRNA), protein levels of TGF-<i>β</i>1, and phosphorylated mothers against decapentaplegic homolog (p-SMAD)2 and p-SMAD3 levels increased in the short hairpin ribonucleic acid- (RNA-) MAP9 (sh-MAP9) MAP9 group compared to the negative control (NC) group. Also, significantly enhanced phosphorylation levels of SMAD2 and SMAD3 were detected in the sh-MAP9 cells. (b) The proliferation ability of both 5637 and T24 cells, detected by Cell Counting Kit-8 (CCK-8) assay and flow cytometry assays, was rescued. 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Journal of Oncology

fig9

Figure 9

Figure 9: MAP9 Exhibits Protumor Activities and Immune Escape toward Bladder Cancer by Mediating TGF-<i>β</i>1 Pathway 

Journal of Oncology

MAP9 Exhibits Protumor Activities and Immune Escape toward Bladder Cancer by Mediating TGF-β1 Pathway

Figure 9