Research Article
HIF-1α Regulates the Progression of Cervical Cancer by Targeting YAP/TAZ
Table 1
According to the histopathological characteristics of the patient and expression of HIF-1α, YAP, and TAZ in CC.
| | Groups | | HIF-1 | | | YAP | | | TAZ | | | | Positive | Negative | Positive | Negative | Positive | Negative |
| | A (normal cervical epithelial) | 30 | 6 (20.0) | 24 (80.0) | | | 7 (23.3) | 23 (76.7) | | | 8 (26.7) | 22 (73.3) | | | | B (CIN) | 58 | 33 (56.9) | 25 (43.1) | | | 34 (58.6) | 24 (41.4) | | | 36 (62.1) | 22 (37.9) | | | | B1 (CINI) | 32 | 15 (46.9) | 17 (53.1) | | | 16 (50.0) | 16 (50.0) | | | 17 (53.1) | 15 (46.9) | | | | B2 (CINII-III) | 26 | 18 (69.2) | 8 (30.8) | | | 18 (69.2) | 8 (30.8) | | | 19 (73.1) | 7 (26.9) | | | | C (CSCC) | 40 | 26 (65.0) | 14 (35.0) | 15.48 | 0.001 | 29 (72.5) | 11 (27.5) | 17.39 | 0.001 | 27 (67.5) | 13 (32.5) | 13.44 | 0.001 | | Differentiation | | | | | | | | | | | | | | | C1 (high) | 19 | 10 (52.6) | 9 (47.4) | | | 11 (57.9) | 8 (42.1) | | | 12 (63.2) | 7 (36.8) | | | | C2 (moderate/poor) | 21 | 16 (76.1) | 5 (23.9) | 2.43 | 0.12 | 18 (85.7) | 3 (14.3) | 3.87 | 0.049 | 15 (71.4) | 6 (28.6) | 0.31 | 0.577 | | L/N metastasis | | | | | | | | | | | | | | | C3 (positive) | 15 | 11 (73.3) | 4 (26.7) | | | 12 (80.0) | 3 (20.0) | | | 13 (86.7) | 2 (13.3) | | | | C4 (negative) | 25 | 15 (60.0) | 10 (40.0) | 0.73 | 0.39 | 17 (68.0) | 8 (32.0) | 0.68 | 0.411 | 14 (56.0) | 11 (44.0) | 4.02 | 0.045 |
|
|
