Bioinformatics Identification of Ferroptosis-Associated Biomarkers and Therapeutic Compounds in Psoriasis

Figure 2

Analyzing differential expressions of ferroptosis-associated genes. (a) Volcano plot of differentially expressed RNA between psoriasis lesions and control samples in the GSE30999 dataset, highlighting the differentially expressed ferroptosis-associated genes. The values marked with dotted lines represented . The top shows the number of upregulated (red) and downregulated (blue) genes. (b) Heatmap of differentially expressed ferroptosis-associated RNA in the GSE30999 dataset. Red represents high expression, and blue represents low expression. The Ward’s minimum-variance hierarchical clustering method was used. (c) The box diagram showing 19 differentially expressed ferroptosis-associated genes in psoriasis and control samples. Gene names were sorted by log2FC value from large to small. The Wilcox test was used. - value <0.0001 compared to control.

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