Research Article

Immune Infiltration and N(6)-Methyladenosine ncRNA Isoform Detection in Acute Lung Injury

Table 2

The function of 11 hub genes.

Gene symbolAbbreviationsFunction

Glucagon-like peptide 1 receptorGLP1RThis gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion [23].
General transcription factor IIH subunit 3GTF2H3This gene encodes a member of the TFB4 family. The encoded protein is a subunit of the core-TFIIH basal transcription factor and localizes to the nucleus [24].
Heterogeneous nuclear ribonucleoprotein LHNRNPLFunctional annotation defined a set of essential spliceosome and RNA binding protein (RBP) genes [25].
RNA polymerase II subunit CPOLR2CThis gene encodes the polymerase responsible for synthesizing messenger RNA in eukaryotes [26].
RhodopsinRHOProtein encoded by this gene is found in rod cells in the back of the eye and is essential for vision in low-light conditions [27].
Sorbin and SH3 domain containing 3SORBS3SORBS3gene codes for the adapter protein vinexin, and has been shown to play a role in growth-factor-induced signal transduction and a cytoskeleton structure [28].
Serpin family a member 10SERPINA10Protein encoded by this gene belongs to the serpin family, predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium, and phospholipid [29].
Mitogen-activated protein kinase 3MAPK3Protein encoded by this gene is a member of the MAP kinase family. MAP kinases, act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals [30].
WASP actin nucleation promoting factorWASIn addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA [31].
EGL-9 family hypoxia inducible factor 2EGLN2EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle [32].
Protein kinase CAMP-activated catalytic subunit alphaPRKACAIn hepatocellular fibrolamellar carcinoma (FL-HCC), the fusion DNAJB1 to PRKACA is suggested to be a diagnostic marker for this rare subtype of HCC [33].