Constructing a Novel Prognostic Signature Based on TGF-β Signaling for Personalized Treatment in Pancreatic Adenocarcinoma

Figure 2

Construction of a 7-gene signature in TCGA-PAAD dataset. (a) The trajectory of each gene (variable) with the changing lambda. Vertical axis indicates the coefficients of each gene, and horizontal axis indicates the lambda value shown as–ln(lambda). Red dotted line represents the position of lambda = 0.0452. (b) The confidence interval of the changing lambda. Red dot corresponds to the red dotted line. (c) The survival status and expression of 7 prognostic genes of 176 samples ranking by risk score. Risk score and mRNA expression were converted to z-score. (d) Kaplan-Meier survival plot of high-risk and low-risk groups. Log-rank test was performed. HR, hazard ratio. CI, confidence interval.

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