lncRNA KCNQ1OT1 Promotes EMT, Angiogenesis, and Stemness of Pituitary Adenoma by Upregulation of RAB11A

Figure 4

Downregulation of lncRNA KCNQ1OT1 expression can inhibit tumor growth in vivo. (a) Downregulation of lncRNA KCNQ1OT1 expression significantly inhibited the tumor growth of HP75 cells in nude mouse models. (b) Tumor volume detection. (c) Tumor weight detection. (d) Real-time PCR analysis showed that after knockout of lncRNA KCNQ1OT1, the expression of lncRNA KCNQ1OT1 in tumor tissues of nude mice was significantly reduced. (e) Real-time PCR analysis showed that after knocking out lncRNA KCNQ1OT1, the expression of E-cadherin in tumor tissues of nude mice was significantly increased. (f) Real-time PCR analysis showed that after knocking out lncRNA KCNQ1OT1, the expression of Vimentin in tumor tissues of nude mice was significantly reduced. (g) Real-time PCR analysis showed that after knocking out lncRNA KCNQ1OT1, the expression of VE-cadherin in tumor tissues of nude mice was significantly reduced. (h) Real-time PCR analysis showed that after knocking out lncRNA KCNQ1OT1, the expression of VEGFR1 in tumor tissues of nude mice was significantly reduced. (i) Real-time PCR analysis showed that after knocking out lncRNA KCNQ1OT1, the expression of VEGFR2 in tumor tissues of nude mice was significantly reduced. (j) Immunohistochemical analysis showed that lncRNA KCNQ1OT1 knockdown can significantly reduce the expression of KI-67. .

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