Research Article
lncRNA KCNQ1OT1 Promotes EMT, Angiogenesis, and Stemness of Pituitary Adenoma by Upregulation of RAB11A
Figure 5
miR-140-5p is the target gene of KCNQ1OT1. (a) The expression of miR-140-5p is downregulated in aggressive pituitary tumor tissues. (b) The coexpression of miR-140-5p and KCNQ1OT1 is negatively correlated. (c) Knockdown KCNQ1OT1 upregulates the expression of miR-140-5p. (d) Schematic diagram of the binding site of miR-140-5p and KCNQ1OT1. (e) The dual luciferase reporter gene detection experiment verifies that miR-140-5p binds to KCNQ1OT1. (f) RNA pull down experiment verified the binding relationship between miR-140-5p and KCNQ1OT1. .
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