Identification of Three Genes Associated with Metastasis in Melanoma and Construction of a Predictive Model: A Multiracial Identification

Figure 5

Validation of the hub genes in our data set by IHC. (a) The hub gene expression in the nonmetastasis melanoma patients and metastasis melanoma in our data set (all ). (b–d) ROC curves and AUC statistics to evaluate the predictive efficiency of the hub genes to distinguish diseases free from metastasis in melanoma patients: (b) SNRPD2, , ; (c) SNRPD3, , ; and (d) EIF4A3, , . (e) The hub gene expression in the pathology stage IV melanoma patients and pathology stage I-III melanoma in our data set (SNRPD2, ; SNRPD3, ; EIF4A3, ). (f–h) ROC curves and AUC statistics to evaluate the predictive efficiency of the hub genes to distinguish pathology stage IV from pathology stage I-III in melanoma patients: (f) SNRPD2, , ; (g) SNRPD3, , ; and (h) EIF4A3, , . (i) The hub gene expression in the nonrecurrence melanoma patients and recurrence melanoma in our data set (all ). (j–l) ROC curves and AUC statistics to evaluate the predictive efficiency of the hub genes to distinguish diseases free from metastasis in melanoma patients: (j) SNRPD2, , ; (k) SNRPD3, , ; and (l) EIF4A3, , .

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)

(k)

(l)