Identification of Three Genes Associated with Metastasis in Melanoma and Construction of a Predictive Model: A Multiracial Identification

Figure 7

Risk factor model construction verified in our data set. (a) The risk factor model of the hub genes in the 147 melanoma patients. Upper: risk score distribution of 147 melanoma patients. Middle: status of every patient in our data set (). Lower: expression heatmap of the hub genes corresponding to each sample above. (b) The DFS analysis of the risk score in the 147 melanoma patients (). (c) The OS analysis of the risk score in the 147 melanoma patients (). (d and e) ROC curves and AUC statistics to evaluate the predictive efficiency of the risk score model: (d) distinguishing pathology stage IV from pathology stage I-III in melanoma patients (, ) and (e) distinguishing diseases free from metastasis in melanoma patients (, ). (f) The risk score in the melanoma patients (metastasis group vs. nonmetastasis group: vs. , ; recurrence group vs. disease-free group: vs. , ). (g and h) Time-dependent AUC curves of the hub genes and risk factor models for the prediction of DFS (g) and OS (h).

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