Identification of Three Genes Associated with Metastasis in Melanoma and Construction of a Predictive Model: A Multiracial Identification

Table 2

Cox regression analysis of predictive factors for disease-free survival in melanoma patients ().

Variables	Univariate analysis			Multivariate analysis
	HR	95% CI	value	HR	95% CI	value
Sex, male/female	0.992	0.648-1.519	0.971
Age	0.990	0.976-1.004	0.174
ASA	1.071	0.750-1.528	0.707
Pathological T stage	2.129	1.605-2.824	<0.001	1.201	0.833-1.731	0.327
Pathological N stage	2.613	2.040-3.347	<0.001	2.034	1.433-2.887	<0.001
Tumor location, skin/other mucosa	1.306	0.852-2.001	0.221
Risk score	1.533	1.348-1.743	<0.001	1.338	1.156-1.549	<0.001
Anemia	1.203	0.581-2.491	0.679
Hypoproteinemia	0.909	0.224-3.696	0.894
NLR	1.025	0.323-3.252	0.966
MLR	1.587	0.591-4.259	0.359
PLR	1.001	0.999-1.003	0.428
SII	1.000	0.998-1.002	0.922

HR: hazard ratio; CI: confidence interval; ASA: American Society of Anesthesiologists; NLR: neutrophil-to-lymphocyte ratio; SII: systemic immune-inflammation index; MLR: monocyte-to-lymphocyte ratio; PLR: platelet-to-lymphocyte ratio.