MSC Senescence-Related Genes Are Associated with Myeloma Prognosis and Lipid Metabolism-Mediated Resistance to Proteasome Inhibitors

Figure 2

Identification of damage-associated genes. (a) A volcano map of genes differentially expressed in MM. Red dots indicate upregulated genes. Green dots indicate downregulated genes. Grey indicates nonsignificant differentially expressed genes. (b) A heatmap of differential gene expression between MM and normal control. Red indicates high expression, and green indicates low expression. (c) A volcano map of genes differentially expressed in MSC senescence. Red dots indicate upregulated genes. Blue dots indicate downregulated genes. Grey indicates nonsignificant differentially expressed genes. (d) A heatmap of differential gene expression in MSC senescence. Red indicates high expression, and blue indicates low expression. (e) A Venn diagram of MSC ageing genes and genes differentially expressed in MM.

(a)

(b)

(c)

(d)

(e)