Epi-miRNAs: Regulators of the Histone Modification Machinery in Human Cancer

Table 5

miRNA-mediated regulation of histone lysine methyltransferases.

Site of methyl group addition	Target gene	miRNAs	Cancer tissue or cancer cell line	Reference
H3K9	SUV39H1 (KMT1A)	miR-125a-5p	Gastric cancer	[83]
	SUV39H1 (KMT1A)	miR-125b	Hepatocellular carcinoma cells	[84]
	SUV39H1 (KMT1A)	miR-122	Hepatocellular carcinoma cells	[85]
	SUV39H2 (KMT1B)	miR-675	Liver stem cells	[86]
	G9a (KMT1C)	miR-212	Lung cancer (NSCLC)	[87]
	SETDB1 (KMT1E)	miR-381-3p	Breast cancer	[88]
H3K4 (MLL1)	Mll1 (KMT2A)	miR-22-3p	Prostatic cancer	[89]
H3K36	ASH1L (KMT2H)	miR-142	Leukemia	[90]
	ASH1L (KMT2H)	miR-142	Thyroid tumors	[91]
	KMT3B (NSD1)	miR-181a	Endometrial cancer	[92]
H4K5	SMYD3 (KMT3E)	miR-124	Cholangiocarcinoma	[93]
	SMYD3 (KMT3E)	miR-346	Hepatocellular carcinoma	[94]
H3K79	DOT1L (KMT4)	miR-133b	Colorectal cancer	[95]
H4K20	SET8 (KMT5A)	miR-502	Breast cancer	[96]
	SET8 (KMT5A)	miR-502	Ovarian cancer	[97]
	SET8 (KMT5A)	miR-502	Non-small-cell lung cancer	[98, 99]
	SET8 (KMT5A)	miR-502	Colorectal cancer	[100]
	SET8 (KMT5A)	miR-502	Non-Hodgkin’s lymphoma	[101]
	SET8 (KMT5A)	miR-502	Esophageal squamous cell carcinoma	[102]
	SET8 (KMT5A)	miR-502	Clear cell renal cell carcinoma	[103]
	SET8 (KMT5A)	miR-502	Hepatocellular carcinoma	[104]
	SET8 (KMT5A)	miR-7	Breast cancer	[105]
H3K27	KMT6B (EZH1)	miR-17-5p	NSCLC	[106]
	KMT6B (EZH1)	miR-765	Breast cancer	[107]
	KMT6B (EZH1)	miR-93	Breast cancer stem cells	[108]
	KMT6B (EZH1)	miR-574-5p	Prostate cancer stem cells	[109]
	KMT6 (EZH2)	miR-101	NSCLC	[110]
	KMT6 (EZH2)	miR-101	Prostate cancer	[111]
	KMT6 (EZH2)	miR-101	renal cancer	[112]
	KMT6 (EZH2)	miR-101	Endometrial cancer	[113]
	KMT6 (EZH2)	miR-26a	Lung cancer	[114]
	KMT6 (EZH2)	miR-26a	Burkitt lymphoma	[115]
	KMT6 (EZH2)	miR-26a	Rhabdomyosarcoma	[116]
	KMT6 (EZH2)	miR-26a	Prostate cancer	[117]
	KMT6 (EZH2)	miR-26a	Nasopharyngeal carcinoma	[118]
	KMT6 (EZH2)	miR-137	Liver cancer	[119]
	KMT6 (EZH2)	miR-124	Hepatocellular cell carcinoma	[120]
	KMT6 (EZH2)	miR-138	Squamous cell carcinoma cell lines	[121]
	KMT6 (EZH2) and HDAC3	miR-31	Esophageal cancer	[125]
	KMT6 (EZH2)	miR-98	Ovarian cancer stem cells	[126]