Epi-miRNAs: Regulators of the Histone Modification Machinery in Human Cancer

Table 7

miRNA-mediated regulation of histone demethylases.

Demethylase groups	Target gene	miRNAs	Cancer tissue or cancer cell line	Reference
KDM1	AOF2 (LSD1)	miR-137	Endometrial cancer	[135]
	AOF2 (LSD1)	miR-302	Hepatocellular carcinoma cells	[136]
	AOF2 (LSD1)	miR-302a and miR-302b	Human head and neck squamous cell carcinomas	[137]
	AOF2 (LSD1)	miR-302	Prostate cancer	[138]
KDM2	FBXL10 (KDM2B)	miR-146b	Ovarian cancer	[139]
	FBXL10 (KDM2B)	miR-448	Gastric cancer	[140]
	FBXL10 (KDM2B)	miR-146a-5p	Cervical cancer cell lines	[141]
KDM3	JMJD1A	miR-627	Colorectal tumors	[142]
	JMJD1A	miR-155	Nasopharyngeal carcinoma	[143]
	JMJD1A	let-7c	NSCLC	[144]
	KDM3A (JMJD1A/JHDM2A)	miR-22	Ewing sarcoma	[145]
KDM4	JMJD2B (KDM4B)	miR-491-5p	Breast cancer	[146]
	JMJD2B (KDM4B)	miR-491-5p	Gastric cancer	[147]
	JMJD2C	miR-335-5p	Prostate cancer	[148]
KDM5	JARID1A (RBP2)	miR-212	Hepatocellular carcinoma	[149]
	JARID1A (RBP2)	miR-212	Gastric cancer	[150]
	JARID1B (KDM5B)	miR-363-3p	Melanoma	[151]
	JARID1B (KDM5B)	miR-137	Acute lymphoblastic leukemia cell lines	[152]
	JARID1B (KDM5B)	miR-138, miR-381-3p, and miR-486-5p	Breast cancer	[153, 154]
KDM7	PHF2	miR-221	Hepatocellular carcinoma	[155]
Arginine demethylase	JMJD6	miR-770	Non-small-cell lung cancer	[156]
	JMJD6	miR-146a and miR-193a	Melanoma	[157]