Molecular Subtypes Based on Cuproptosis-Related Genes and Tumor Microenvironment Infiltration Characterization in Colorectal Cancer

Figure 5

Construction, validation, and evaluation of CRG-score model. (a) Alluvial diagram of subtype distributions in groups with different CRG-scores and DFS. (b) Differences in CRG-scores between cuproptosis clusters A and C. (c) Differences in CRG-scores between two gene subtypes. (d) Kaplan–Meier curves analysis for DFS of CRC patients between high-risk and low-risk groups in the training and testing sets. (e) ROC curves of the CRG-scores to demonstrate the sensitivity and specificity in predicting the DFS of CRC patients from training and testing sets. (f) Differences in TME score between two gene subtypes. (g) Ranked dot and scatter plots showing the correlation between CRG-score and 22 infiltrating immune cell types. (h) Correlations between the abundance of immune cells and eight genes from the CRG-score model.

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