NCOA4: An Immunomodulation-Related Prognostic Biomarker in Colon Adenocarcinoma and Pan-Cancer

Figure 10

NCOA4-related genes enrichment and pathway analysis in pan-cancer. (a) Protein-protein interaction network was analyzed by STRING. (b) Heatmap representation of the expression correlation data between NCOA4 and FTL, FTH1, HERC2, RNF14, AR, ESR1, PTCH1, RET, CUX1, and CCDC6 in all TCGA tumors. The red color indicates a positive correlation (0-1), while the blue indicates a negative correlation (−1-0). (c) GO/KEGG pathway based on the top 100 NCOA4-related genes in the TCGA database. (d) Expression correlation between NCOA4 and the top 10 NCOA4-related genes (CNOT6L, REB2, KIAA1033, HEATR5B, HIPK3, PIKFYVE, POLK, ELF2, and FBXO38) in the TCGA database as determined by GEPIA2 tool. The r ranges from −1 to 1, where |r| ≥ 0.7 signifies a high positive correlation, 0.5 ≤ |r| < 0.7 is a moderate positive correlation, 0.3 ≤ |r| < 0.5 is a low positive correlation, and |r| < 0.3 is a negligible correlation.

(a)

(b)

(c)

(d)