Matrix Metalloproteinases and Stress Hormones in Lung Cancer Progression

Figure 2

MMP-2 and MMP-9 gelatinase activity in serum from lung cancer patients. Zymography assay showed a rise in the gelatinase activity of MMP-2 and MMP-9 in serum from most lung cancer patients, particularly in the W (b), N (c), and TS (d) groups. Disease stages are indicated at the top of each gel. (a) Control group; (b) LAC associated with wood smoke exposure, W group; (c) LAC patients with no recognizable risk factor, N group; (d) LAC associated with tobacco smoking, TS group; (e) LAC associated with passive smoking, PS group; (f) LAC associated with tobacco smoking and wood smoke exposure, TW group. Abbreviations: LAC: lung adenocarcinoma; H: HT-1080 fibrosarcoma cell medium used as an enzymatic activity control; aMMP-2: active MMP-2; aMMP-9: active MMP-9; pMMP-9: pro-MMP-9 (latent enzyme).

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