miR-187/PDLIM1 Gets Involved in Gastric Cancer Progression and Cisplatin Sensitivity of Cisplatin by Mediating the Hippo-YAP Signaling Pathway

<div>miR-187 targets PDLIM1. (a) The Starbase database (<a href="http://starbase.sysu.edu.cn/">http://starbase.sysu.edu.cn/</a>) forecast the binding target of PDLIM1 and miR-187. (b, c) Dual luciferase activity assay and RIP corroborated the binding relationship between PDLIM1 and miR-187. (d) The coexpressed genes of miR-187 in GC (LindOmics). The heat maps exhibited the positively and negatively coexpressed Top-50 genes of miR-187 in GC. (e) PDLIM1 was negatively correlated with miR-187 in GC. (f) RT-qPCR confirmed PDLIM1 expression in MKN-45 cells. ns <span class="nowrap"><svg height="9.2729pt" id="M55" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -8.6359 44.8393 9.2729" width="44.8393pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z"></path></g><g transform="matrix(.013,0,0,-0.013,11.658,0)"><path d="M512 230V281L75 514V456L453 256V254L75 55V-3L512 230Z"></path></g><g transform="matrix(.013,0,0,-0.013,22.921,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 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Journal of Oncology

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Figure 6

Figure 6: miR-187/PDLIM1 Gets Involved in Gastric Cancer Progression and Cisplatin Sensitivity of Cisplatin by Mediating the Hippo-YAP Signaling Pathway 

Figure 6 | miR-187/PDLIM1 Gets Involved in Gastric Cancer Progression and Cisplatin Sensitivity of Cisplatin by Mediating the Hippo-YAP Signaling Pathway 