Exosomes Derived from Tumor Cells Initiate Breast Cancer Cell Metastasis and Chemoresistance through a MALAT1-Dependent Mechanism

Figure 9

Schematic diagram of the mechanism by which MALAT1 delivered by BC cell-derived Exo affects BC metastasis and chemoresistance. BC cell-derived Exo deliver MALAT1, which downregulates miR-1-3p, and upregulates VASP, thereby activating the Rap1 signaling pathway to promote BC metastasis and chemoresistance.