Licoflavone A Suppresses Gastric Cancer Growth and Metastasis by Blocking the VEGFR-2 Signaling Pathway

Figure 6

LA suppressed GC growth and metastasis in VEGF-stimulated MKN-45 cells through PI3K/AKT and MEK/ERK signaling pathway activation. (a) Western blot analysis of PI3K, p-PI3K, AKT, p-AKT, MEK, p-MEK, ERK, and p-ERK in LA-treated VEGF-stimulated MKN-45 cells. (b and c) RT-PCR analysis of PI3K, AKT, MEK, and ERK mRNA relative expression in LA-treated VEGF-stimulated MKN-45 cells. The data are presented as (). vs. and vs. . ^# vs. , ^## vs. .

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