Gene Expression Analysis Reveals Prognostic Biomarkers of the Tyrosine Metabolism Reprogramming Pathway for Prostate Cancer

Figure 5

Establishment of the signature based on tyrosine metabolism-related genes. (a) Partial likelihood deviance of different numbers of variables; (b) the LASSO coefficient profiles of the selected four features; (c) the heatmap plot showed the distribution of four selected genes between different clinicopathological features; (d) the Kaplan–Meier plot and log-rank analysis showed the survival outcome difference between low- and high-risk subgroups in the TCGA training cohort; (e) the ROC curve showed the predictive value of the four gene-based signatures in the training cohort; (f) the Kaplan-Meier plot and logrank analysis showed the survival outcome difference between low- and high-risk subgroups in the TCGA validation cohort; (g) the ROC curve showed the predictive value of the four gene-based signatures in the validation cohort.

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