Exosome-Mediated miR-4792 Transfer Promotes Bladder Cancer Cell Proliferation via Enhanced FOXC1/c-Myc Signaling and Warburg Effect

Figure 1

Downregulation of FOXC1 significantly suppressed bladder tumor cell growth and aerobic glycolysis. (a) The CCK8 assay was used to measure the number of 253J and 5637 cells at 0, 12, 24, and 48 h  < 0.01,  < 0.001 vs. shNC. (b, c) OCR and ECAR were examined using a Seahorse XF24 analyzer. A xenograft nude mouse tumor model was established using 5637 stable cell lines. (d) Lactic acid content was measured.  < 0.01 vs. shNC. (e) The tumor size was measured with a caliper.  < 0.05 vs. shNC. shNC: n = 6; shFOXC1: n = 6. (f) The size of the dissected tumors was indicated by a ruler, and tumor weight was determined.  < 0.01 vs. shNC. (shNC: n = 6; shFOXC1: n = 6).

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