Exosome-Mediated miR-4792 Transfer Promotes Bladder Cancer Cell Proliferation via Enhanced FOXC1/c-Myc Signaling and Warburg Effect

Figure 3

Exosome-mediated miR-4792 delivery significantly inhibited cell growth and aerobic glycolysis in 253J and 5637 cells. After miR-4792 inhibitor treatment (antagomir) and agomir mimic transfection of hAMSCs, exosomes were extracted from hAMSCs. (a) The CCK8 assay was used to measure the number of cells at 0, 12, 24, and 48 h  < 0.05,  < 0.01 vs. vehicle; # < 0.05, ## < 0.01 vs. hAMSC_exo + NC. (b, c) OCR and ECAR were measured using a Seahorse XF24 analyzer. (d) Lactic acid content was measured. (e) Expression levels of miR-4792 and FOXC1 were detected through qRT-PCR.  < 0.01 vs. vehicle; # < 0.05, ## < 0.01 vs. hAMSC_exo + NC.

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