Association between Cervical Lymph Node Metastasis and the Incidence of Radiation-Induced Hypothyroidism in Nasopharyngeal Carcinoma
Table 2
Univariate analysis of radiation-induced HT.
Variables
Beta
OR (95% CI)
Age
−0.02
0.98 (0.95–1.00)
0.076
Sex
0.93
2.53 (1.38–4.64)
0.003
Pretreatment TSH concentration
1.2
3.33 (2.24–4.95)
<0.001
Volume (cm3)
−0.13
0.88 (0.83–0.94)
<0.001
T-Stage (T1–2 vs. T3–4)
0.00
1.00 (0.50–2.01)
0.996
N-stage (N2–3 vs. N0–1)
0.59
1.80 (1.00–3.22)
0.048
M-Stage (M1 vs. M0)
0.56
1.75 (0.43–7.21)
0.437
Clinical stage (III–IV vs I–II)
0.17
1.18 (0.40–3.50)
0.763
Neoadjuvant chemotherapy (yes vs. no)
0.52
1.69 (0.52–5.50)
0.386
Distance from thyroid 1–2 cm (vs. 0–1 cm)
−0.17
−0.17 (0.34–2.05)
0.703
Distance from thyroid 2–3 cm (vs. 0–1 cm)
−0.8
−0.80 (0.20–1.02)
0.056
Distance from thyroid >3 cm (vs. 0–1 cm)
−1.31
−1.31 (0.12–0.63)
0.002
N.Ib (1∼2 vs 0)
0.31
0.31 (0.51–3.68)
0.536
N.Ib (3+ vs 0)
−14.71
−14.71 (0.00-Inf)
0.987
N.IIa (1∼2 vs 0)
1.2
1.20 (1.11–9.81)
0.031
N.IIa (3+ vs 0)
0.63
0.63 (0.51–6.98)
0.342
N.IIb (1∼2 vs 0)
1.87
1.87 (2.05–20.59)
0.001
N.IIb (3+ vs 0)
1.32
1.32 (1.12–12.51)
0.032
N.III (1∼2 vs 0)
0.48
0.48 (0.85–3.09)
0.143
N.III (3+ vs 0)
0.95
0.95 (1.20–5.58)
0.015
N.IVa (1∼2 vs 0)
0.86
0.86 (1.25–4.43)
0.008
N.IVa (3+ vs 0)
1.29
1.29 (1.11–11.83)
0.033
N.IVb (1∼2 vs 0)
15.45
5112076.84 (0.00-Inf)
0.983
N.Va (1∼2 vs 0)
0.55
0.55 (0.97–3.09)
0.064
N.Va (3+ vs 0)
1.89
1.89 (0.77–56.65)
0.084
N.Vb (1∼2 vs 0)
0.57
1.77 (0.86–3.63)
0.119
N.Vc (1∼2 vs 0)
0.26
1.29 (0.21–7.90)
0.782
N.VIIa (1∼2 vs 0)
−0.09
0.91 (0.49–1.70)
0.774
Maxdiameter.Ib (0, 1) cm
−0.14
−0.14 (0.29–2.58)
0.802
Maxdiameter.Ib ≥ 1 cm
1.25
1.25 (0.38–31.69)
0.269
Maxdiameter.IIa (0, 1) cm
1.02
1.02 (0.92–8.39)
0.069
Maxdiameter.IIa ≥ 1 cm
1.29
1.29 (1.15–11.52)
0.028
Maxdiameter.IIb (0, 1) cm
1.72
1.72 (1.73–17.86)
0.004
Maxdiameter.IIb ≥ 1 cm
1.66
1.66 (1.63–17.03)
0.006
Maxdiameter.III (0, 1) cm
0.71
0.71 (1.10–3.80)
0.024
Maxdiameter.III ≥ 1 cm
0.29
0.29 (0.52–3.42)
0.55
Maxdiameter.IVa (0, 1) cm
0.93
0.93 (1.36–4.67)
0.003
Maxdiameter.IVa ≥ 1 cm
1.04
1.04 (0.70–11.38)
0.146
Maxdiameter.IVb (0, 1) cm
15.45
15.45 (0.00-Inf)
0.988
Maxdiameter.IVb ≥ 1 cm
15.45
15.45 (0.00-Inf)
0.988
Maxdiameter.Va (0, 1) cm
0.69
0.69 (1.09–3.64)
0.026
Maxdiameter.Va ≥ 1 cm
0.39
0.39 (0.48–4.49)
0.498
Maxdiameter.Vb (0, 1) cm
0.46
0.46 (0.73–3.46)
0.244
Maxdiameter.Vb ≥ 1 cm
1.05
1.05 (0.56–14.58)
0.206
Maxdiameter.Vc (0, 1) cm
−0.15
−0.15 (0.12–6.23)
0.882
Maxdiameter.Vc ≥ 1 cm
14.42
14.42 (0.00-Inf)
0.987
Maxdiameter.VIIa (0, 1) cm
0.00
−0.00 (0.52–1.93)
1
Maxdiameter.VIIa ≥ 1 cm
−0.31
−0.31 (0.33–1.62)
0.441
N. all
0.1
1.11 (1.03–1.19)
0.008
Maxdiameter.all
0.59
1.81 (1.03–3.18)
0.04
OR = odds ratio; CI = confidence interval; Distance from thyroid = the shortest distance between metastatic lymph nodes and the thyroid gland; N = number. ,,.
