Prp19 Facilitated p21-Dependent Senescence of Hepatocellular Carcinoma Cells

Figure 3

Prp19 modulates p21 expression in L02 cells and HCC cells. (a) Western blot assay of p16, p21, and p53 expression in L02 cells overexpressing Prp19. (b) Western blot assay of p16, p21, and p53 expression in HCC cells with Prp19 knockdown. (c) Relative levels of Prp19 and p21 transcripts in human HCC cell lines were determined by qRT-PCR. Levels of mRNA were normalized to ACTIN and presented relative to the control cells. Negative control, NC. The data are shown as the mean ± SEM. .

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