Prp19 Facilitated p21-Dependent Senescence of Hepatocellular Carcinoma Cells

<div>Prp19 knockdown promotes tumor growth of HCC <i>in vivo</i>. (a) Prp19 protein expression of stable HCC cell lines misexpressing Prp19. (b) Images of the subcutaneous xenograft tumors generated by HCC cells misexpressing Prp19 in nude mice. The weights of the xenograft tumors are summarized in the lower panel. (c) Comparison of tumor size at the indicated time after implantation (<i>n</i> = 5). (d) Representative images of HE, IHC staining of Prp19 and p21, and SA-<i>β</i>-galactosidase staining in xenograft tumors (original magnification 200x). (e) Prp19 and p21 protein expression in xenograft tumors. (f) Statistically analysis of SA-<i>β</i>-galactosidase positive cells in xenograft tumors. 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Journal of Oncology

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Figure 4

Figure 4: Prp19 Facilitated p21-Dependent Senescence of Hepatocellular Carcinoma Cells 