A Systematic Review and Meta-Analysis on the Prognostic Value of BRCA Mutations, Homologous Recombination Gene Mutations, and Homologous Recombination Deficiencies in Cancer

<div>A HRD positivity (standard definition) and OS. A random-effects meta-analysis of 4 studies regarding the therapeutic effects comparing HRD high levels to low levels among all patients. Each square indicates the hazard ratio (HR) for overall survival (OS) in each study. The square size is proportional to the precision of HR (inverse of variance). The horizontal line represents the 95% confidence interval. Studies are ordered by the year of publication. The pooled HR and 95% CI are indicated by the dashed line and diamond, respectively; the black vertical line represents the null hypothesis.</div>

Journal of Oncology

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Figure 6: A Systematic Review and Meta-Analysis on the Prognostic Value of BRCA Mutations, Homologous Recombination Gene Mutations, and Homologous Recombination Deficiencies in Cancer 

Figure 6 | A Systematic Review and Meta-Analysis on the Prognostic Value of BRCA Mutations, Homologous Recombination Gene Mutations, and Homologous Recombination Deficiencies in Cancer 