Kupffer Phase Radiomics Signature in Sonazoid-Enhanced Ultrasound is an Independent and Effective Predictor of the Pathologic Grade of Hepatocellular Carcinoma

Table 2

Univariate analysis and multivariate analysis for p-HCC versus w/m-HCC.

Variables	Univariate				Multivariate
	log (OR)	(0.025	0.975)		log (OR)	(0.025	0.975)
AFP	0.000	0.000	0.000	1.000
TBil	0.001	−0.007	0.009	0.788
DBil	0.000	−0.007	0.008	0.951
AST	0.004	0.000	0.010	0.263
ALT	0.005	−0.003	0.012	0.195
CA125	−0.001	−0.005	0.002	0.451
CA19-9	0.003	−0.007	0.013	0.606
CA153	−0.011	−0.061	0.040	0.671
grayRS	0.145	−4.763	5.054	0.954
APRS	−6.533	−11.339	−1.728	0.023	−9.132	−18.686	0.422	0.061
KPRS	14.940	7.313	22.567	<0.001	15.869	7.218	24.520	<0.001
const.					−1.363	−3.693	0.968	0.252

AFP, alpha-fetoprotein; TBil, total bilirubin; DBil, direct bilirubin; AST, aspartate transaminase; ALT, alanine transaminase; CA, carbohydrate antigen; grayRS, grayscale radiomic score; APRS, arterial phase radiomic score; KPRS, Kupffer phase radiomic score; const., constant.