Posttranslational Modifications of Rev-Erbα Protein and Abnormal Inflammatory Response in Gastric Cancer

Figure 2

MNU/H. pylori decreases the levels of Rev-erbα in gastric cancer tissues of mice accompanied by an increase in the level of lactic acid. After C57BL/6J mice were exposed to MNU (200 ppm) for 10 weeks, they were inoculated with H. pylori (5 × 10⁹ CFU/time, 5 times in total). After 6 or 12 months (m) of MNU exposure, the levels of Rev-erbα protein (a), (b), and lactic acid (c) in the gastric tissues of mice were measured. Mean ± SEM, N  = 8. , vs corresponding controls (Ctr); ^††, ^††† vs MNU/H. pylori (6 m).

(a)

(b)

(c)