Research Article
Posttranslational Modifications of Rev-Erbα Protein and Abnormal Inflammatory Response in Gastric Cancer
Figure 4
Rev-erbα protein SUMOylation and ubiquitination modifications are significantly increased in gastric cancer cells line BGC-823 and in MNU/H. pylori-induced moues gastric tumor tissues. (a, b) Rev-erbα protein SUMOylation and ubiquitination modifications in normal human gastric mucosal epithelial cells (GES-1), human gastric cancer cell lines (BGC-823) (a), control mouse gastric tissues (Ctr), and MNU/H. pylori-induced mice gastric cancer tissues (b) were detected by immunoprecipitation. (c, d) Ubiquitin, SUMO1, and SUMO2 were standardized with the corresponding Rev-erbα. Mean ± SEM, N = 4–5. vs GES-1 or Ctr. IP: immunoprecipitation; IB: immunoblot.
(a) |
(b) |
(c) |
(d) |