Integrative Analysis of Bulk RNA-Seq and Single-Cell RNA-Seq Unveils the Characteristics of the Immune Microenvironment and Prognosis Signature in Prostate Cancer

Figure 1

Multiple functions of DEGs have been identified in the cancer genome atlas prostate cancer (TCGA-PRAD) cohort. (a) DEGs between PRAD and control samples were identified using fold-change values and adjusted -values. DEGs, differentially expressed genes; PRAD, prostate cancer; Control, normal tissue. Red and blue dots indicate upregulated and down-regulated mRNAs, respectively. Statistical significance was set at -value <0.05. (b). DEGs enriched in the gene ontology (GO) pathways. BP, biological process; CC, cellular component; MF, molecular function. Adjusted value <0.05 was considered statistically significant. (c) DEGs enriched in the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Adjusted value <0.05 was considered statistically significant.

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