Integrative Analysis of Bulk RNA-Seq and Single-Cell RNA-Seq Unveils the Characteristics of the Immune Microenvironment and Prognosis Signature in Prostate Cancer

<div>Expression profiles of hub differentially infiltrated immune cell-related genes (DIICRGs) in cell subpopulations. (a) The characteristic variance diagram displays the genes with significant differences across cells. (b) Line chart displaying the significantly available dimensions of data sets with <svg height="10.2124pt" id="M25" style="vertical-align:-3.42943pt" version="1.1" viewbox="-0.0498162 -6.78297 7.83752 10.2124" width="7.83752pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M570 304C570 398 525 448 414 448C385 448 343 445 312 434L329 511L321 518C297 504 262 482 244 460L233 411C195 397 159 381 128 358L135 332C160 347 189 360 224 373L111 -147C97 -210 84 -218 17 -231L13 -257L254 -247L259 -218L233 -216C183 -212 177 -202 189 -142L218 -1C238 -10 266 -12 283 -12C351 3 429 48 483 105C543 168 570 242 570 304ZM482 289C482 161 380 33 304 33C278 33 248 51 233 69L303 396C326 400 352 403 369 403C428 403 482 380 482 289Z"></path></g></svg> value &lt;0.05, which were identified using principal component analysis. PC, principal component. (c) The annotated cell subpopulations using SingleR. (d) Mapping of hub gene expressions in the epithelial, tissue stem and endothelial cells via the tSNE method. (e) Hub gene expressions in the epithelial, tissue stem and endothelial cells.</div>

Journal of Oncology

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Figure 5

Figure 5: Integrative Analysis of Bulk RNA-Seq and Single-Cell RNA-Seq Unveils the Characteristics of the Immune Microenvironment and Prognosis Signature in Prostate Cancer 

Figure 5 | Integrative Analysis of Bulk RNA-Seq and Single-Cell RNA-Seq Unveils the Characteristics of the Immune Microenvironment and Prognosis Signature in Prostate Cancer 