Integrative Analysis of Bulk RNA-Seq and Single-Cell RNA-Seq Unveils the Characteristics of the Immune Microenvironment and Prognosis Signature in Prostate Cancer

Table 1

Roles of the 25 genes used in the prognosis signature.

Gene	Role	References
ABCA2	Drug resistance and malignant progression	Zhu et al. [95]; pasello et al. [96]
ABCB6	Progression	Karatas et al. [97]
ABCB9	Drug resistance	Guazzelli et al. [98]
ACAP3	Prosurvival role	Sullivan et al. [99]
ACIN1	Belongs to the canonical apoptosis signaling pathway	Ali et al. [100]
ACOX2	Tumour progression	Bjørklund et al. [101]
ACRBP	Paclitaxel resistance	Whitehurst et al. [102]
ACYP1	Tumorigenesis and progression; poor prognosis	Zhou et al. [103]
ADAM11	Tumour suppressor	Ribeiro et al. [104]
ADAMTS2	The inhibition of proliferation and angiogenesis of endothelial cells	Kirana et al. [105]
ADAP1	Metastasis and invasion	Oga et al. [106]
ADAP2	a key accessory protein for relaying signals via natural killer cell receptors	Campbell and colonna [107]
ABCC5	Accelerating tumour growth and migration	Ji et al. [108]
ADCK2	The proliferation and survival of cancer cells; regulation of superoxide activity	Vierthaler et al. [109]; schoolmeesters et al. [110]
ADH5	Associated with disease-free survival and metabolic functions
ADRA1D	Related to benign prostatic hyperplasia	Kim et al. [111]
AGAP2	Facilitating the growth of the prostate	Zhao et al. [112]
AGAP3	Putative driver gene	Shimizu et al. [113]
AGRN	Critical to the tumour-promoting function of long noncoding RNA NEAT1	Li et al. [114]
AHRR	Tumour suppressor	Burris et al. [115]
AIFM1	The induction of apoptosis in a caspase-independent manner	Liu et al. [116]
AK5	Apoptosis inhibition and autophagy promotion	Zhang et al. [117]
AKAP7	Progression by regulating miR-526b-5p and SERP1	Mekhail et al. [118]
AKR1C3	Promoting epithelial-mesenchymal transition and metastasis by activating ERK signaling	Wang et al. [119]
ALDH1A2	Reduction in ALDH1A2 protein is an early event in human prostate cancer	Kim et al. [120]