Prognostic Nomograms Based on the Cirrhotic Severity Scoring for Preoperative Prediction of Long-Term Outcomes in Patients with HBV-Related Hepatocellular Carcinoma and Child-Pugh Grade A Liver Function

Table 3

Univariate analysis of risk factors influencing recurrence-free and overall survival based on the preoperative data.

Variables	Recurrence-free survival		Overall survival
	HR (95% CI)		HR (95% CI)
Age, years
>60 vs. ≤60	0.990 (0.769-1.274)	0.936	1.180 (0.878-1.586)	0.272
Gender
Male vs. female	1.001 (0.726-1.380)	0.996	0.893 (0.605-1.319)	0.569
Alanine aminotransferase, U/L
>40 vs. ≤40	1.331 (1.095-1.618)	0.004	1.362 (1.072-1.731)	0.012
ALBI grade
Grade 2 vs. grade 1	1.374 (1.141-1.654)	0.001	1.588 (1.262-1.998)	<0.001
Prothrombin time, seconds
>14 vs. ≤14	1.074 (0.875-1.318)	0.495	1.046 (0.808-1.352)	0.735
AFP, ng/mL
>400 vs. ≤400	1.442 (1.196-1.738)	<0.001	1.647 (1.309-2.072)	<0.001
CSS
Moderate cirrhosis vs. no/mild cirrhosis	1.277 (1.033-1.578)	0.024	1.329 (1.021-1.730)	0.035
Severe cirrhosis vs. no/mild cirrhosis	1.676 (1.290-2.177)	<0.001	2.279 (1.672-3.107)	<0.001
Tumor number
Multiple vs. single	2.470 (1.974-3.089)	<0.001	2.230 (1.703-2.921)	<0.001
Tumor size, cm
>5 vs. ≤5	1.763 (1.461-2.128)	<0.001	1.825 (1.443-2.309)	<0.001
Macrovascular invasion
Present vs. absent	2.952 (2.270-3.841)	<0.001	4.690 (3.497-6.289)	<0.001

ALBI: albumin-bilirubin; AFP: alpha-fetoprotein; CSS: cirrhotic severity scoring.