Prognostic Nomograms Based on the Cirrhotic Severity Scoring for Preoperative Prediction of Long-Term Outcomes in Patients with HBV-Related Hepatocellular Carcinoma and Child-Pugh Grade A Liver Function

Table 4

Independent prognostic factors for recurrence-free and overall survival by multivariate analysis.

Variables	Recurrence-free survival		Overall survival
	HR (95% CI)		HR (95% CI)
Alanine aminotransferase, U/L
>40 vs. ≤40	1.171 (0.959-1.430)	0.121	1.182 (0.926-1.510)	0.180
CSS
Moderate cirrhosis vs. no/mild cirrhosis	1.271 (1.022-1.580)	0.031	1.340 (1.023-1.756)	0.034
Severe cirrhosis vs. no/mild cirrhosis	1.772 (1.353-2.319)	<0.001	2.666 (1.934-3.676)	<0.001
ALBI grade
Grade 2 vs. grade 1	1.191 (0.984-1.440)	0.073	1.385 (1.095-1.751)	0.007
AFP, ng/mL
>400 vs. ≤400	1.285 (1.055-1.566)	0.013	1.516 (1.185-1.940)	0.001
Tumor number
Multiple vs. single	2.186 (1.743-2.741)	<0.001	1.859 (1.411-2.449)	<0.001
Tumor size, cm
>5 vs. ≤5	1.496 (1.217-1.840)	<0.001	1.448 (1.117-1.877)	0.005
Macrovascular invasion
Present vs. absent	2.302 (1.753-3.022)	<0.001	3.720 (2.728-5.072)	<0.001

ALBI: albumin-bilirubin; AFP: alpha-fetoprotein; CSS: cirrhotic severity scoring.