Tumor Characteristics Associated with Lymph Node Metastasis and Prognosis in Patients with ERBB2-Positive Gastric Cancer

Table 2

Univariate analyses of risk factors for lymph node metastasis.

Variable	Nodal-positive group	Nodal-negative group	χ2	value
Gender			0.301	0.583
Male	67	31
Female	15	9
Age (years)			0.084	0.772
≤60	14	6
>60	68	34
Tumor size			7.342	0.007
≤4 cm	36	28
>4 cm	46	12
Depth of invasion			22.987	<0.001
PT1	2	13
PT2	6	3
PT3	41	16
PT4a/PT4b	33	8
Histologic classification			0.606	0.436
Moderately differentiated	41	17
Moderately poorly differentiated	32	22
Poorly differentiated	9	1
Histology			2.173	0.140
Conventional AD	65	36
Mucinous AD	7	3
Papillary AD	4	0
Signet-ring cell carcinoma	6	0
Adenosquamous carcinoma	0	1
Tumor location			3.334	0.343
Upper 1/3	27	14
Middle 1/3	5	5
Lower 1/3	39	19
Mix	11	2
Vascular invasion			31.991	<0.001
(−)	25	34
(+)	57	6
Neural invasion			13.922	<0.001
(−)	32	30
(+)	50	10
Lauren type			1.600	0.206
I (intestinal type)	70	38
D (diffuse type)	5	2
M (mixed type)	7	0
Tumor deposit			3.940	0.047
Yes	18	3
No	64	37

Abbreviations: AD-adenocarcinoma.