Tumor Characteristics Associated with Lymph Node Metastasis and Prognosis in Patients with ERBB2-Positive Gastric Cancer

Table 4

Cox regression analysis of prognostic factors for overall survival.

Variable	Univariate analyses				Multivariable analyses
	Number (n)	3-OS (%)	χ2	value	Hazard ratio (95% CI)	value
Age (years)			0.031	0.861
≤60	20	54.5
>60	102	59.1
Gender			1.404	0.236
Male	98	61.7
Female	24	44.7
Tumor size (cm)			3.699	0.054
≤4 cm	64	66.3
>4 cm	58	49.7
Depth of invasion			35.969	<0.001	4.615 (2.182–9.759)	<0.001
PT1-3	81	79.8
PT4	41	7.8
Lymph node metastasis			17.360	<0.001	2.718 (0.863–8.564)	0.088
No	40	86.0
Yes	82	44.0
Histologic classification			2.003	0.367
Middle-differentiated	58	64.2
Middle-poor differentiated	54	55.5
Poor-differentiated	10	45.0
Histology			0.061	0.805
Conventional AD	101	60.6
Other	21	44.0
Type of gastrectomy			0.418	0.811
Proximal subtotal gastrectomy	20	48.3
Distal gastrectomy	28	56.4
Total gastrectomy	44	65.5
Type of surgery			0.170	0.680
Open surgery	56	60.7
Laparoscopic surgery	66	55.7
Neural invasion			18.978	<0.001	1.566 (0.732–3.354)	0.248
(−)	62	75.8
(+)	60	39.7
Vascular invasion			28.518	<0.001	3.036 (1.369–6.736)	0.006
(−)	59	78.8
(+)	63	35.3
Lauren type			8.825	0.003	2.175 (0.963–4.915)	0.062
I (intestinal type)	108	61.3
D-M (diffuse-mix type)	14	41.7
Tumor deposit			7.847	0.005	0.849 (0.413–1.747)	0.849
Yes	21	13.5
No	101	66.5
Subgroup analysis (AJCC stage II–IV)
Chemotherapy approach			3.511	0.061
S-1	36	39.3
CapeOX/SOX	69	56.3