Neferine Exerts Ferroptosis-Inducing Effect and Antitumor Effect on Thyroid Cancer through Nrf2/HO-1/NQO1 Inhibition

<div>Neferine restrained the invasion and EMT of thyroid cancer cells. IHH-4 and CAL-62 cells were exposed with 5 and 10 <i>μ</i>M neferine for 96 h. (a) The invaded cell numbers were detected by transwell assays. (b–e) The relative protein expression of VEGF, E-cadherin, N-cadherin, and vimentin was analyzed by the western blot assay. 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All assays were performed in triplicate.</div>

Journal of Oncology

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Figure 2

Figure 2: Neferine Exerts Ferroptosis-Inducing Effect and Antitumor Effect on Thyroid Cancer through Nrf2/HO-1/NQO1 Inhibition 