ST8SIA6-AS1 Promotes the Epithelial-to-Mesenchymal Transition and Angiogenesis of Pituitary Adenoma

Figure 7

Downregulation of ST8SIA6-AS1 expression can inhibit tumor growth in vivo. (a) Downregulation of ST8SIA6-AS1 expression significantly inhibited tumor growth in GTI-1 cells in the nude mouse model. (b) Tumor volume detection. (c) Tumor weight detection. (d) Real-time PCR analysis showed that the expression of ST8SIA6-AS1 was significantly decreased in tumor tissues of nude mice after knockout of ST8SIA6-AS1. (e) Real-time PCR analysis showed that the expression of miR-5195-3p was significantly increased in tumor tissues of nude mice after knockout of ST8SIA6-AS1. (f) Immunohistochemical analysis showed that the expression of HOXA9 was significantly reduced in tumor tissues of nude mice after the knockout of ST8SIA6-AS1. (g) Real-time PCR analysis showed changes in the expression of E-cadherin and vimentin in tumor tissues of nude mice after knockout of ST8SIA6-AS1. , . Magnification 400x.

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