Long Intergenic Noncoding RNA 00641 Promotes Growth and Invasion of Colorectal Cancer through Regulating miR-450b-5p/GOLPH3 Axis

<div>miR-450b-5p overexpression inhibited the malignant behavior of CRC cells <i>in vitro.</i> (a) qRT-PCR analysis showed that miR-450b-5p overexpression in the transfected SW480 and HTC-116 cell lines. (b) The proliferation of SW480 and HCT-116 was determined by MTT assay when miR-450b-5p was increased. (c), (d) The effect of miR-450b-5p on cell cycle and apoptosis was determined by flow cytometry. (e), (f) Ectopic expression of miR-450b-5p inhibited the migration and invasion ability of SW480 and HCT-116 cells, which was detected using transwell assay. Data are represented as mean ± SD of three biological replicates. 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Journal of Oncology

fig4

Figure 4

Figure 4: Long Intergenic Noncoding RNA 00641 Promotes Growth and Invasion of Colorectal Cancer through Regulating miR-450b-5p/GOLPH3 Axis 