Dissection of Immune Profiles in Microsatellite Stable and Low Microsatellite Instability Colon Adenocarcinoma by Multiomics Data Analysis

Figure 2

Comparisons of immune signature enrichment and clinical outcomes among the three immune subtypes. Comparisons of the enrichment scores of immunostimulatory signatures (M1 macrophages, activated CD8 T cells, and NK cells) and immunosuppressive signatures (M2 macrophages, regulatory T cells, myeloid-derived suppressor cells (MDSCs), and PD-L1) (a), ratios of immunostimulatory to immunosuppressive signatures (M1/M2 macrophages) (b), and the percentage of tumor-infiltrating lymphocytes (TILs) (c) among the three immune subtypes. The Kruskal–Wallis test (a), one-way ANOVA (b), and one-tailed Mann–Whitney test (c). values are shown. , , , and ^ns. It also applies to the following figures. (d) Comparisons of overall survival (OS) and disease-free survival (DFS) rates among the immune subtypes by the Kaplan–Meier curves. The log-rank test values are shown. (e) Comparisons of the response (complete or partial response) rates to chemotherapy among the three immune subtypes in TCGA-COAD. The chi-square test value is shown.

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