Research Article
Bone Mesenchymal Stem Cell-Derived Exosome-Enclosed miR-181a Induces CD4+CD25+FOXP3+ Regulatory T Cells via SIRT1/Acetylation-Mediated FOXP3 Stabilization
Figure 3
BMSC-derived exosome miR-181a treatment triggers the conversion of effector T cells into FOXP3+-expressing Tregs. (a) The frequency of CD4+CD25+FOXP3+ Treg cells in CD4+ T cells cocultured with BMSC-derived exosomes analyzed by flow cytometry. . (b) miR-181a expression in CD4+ T cells treated with NC or miR-181a inhibitor-transfected BMSC-derived exosomes measured by RT-qPCR assay. . (c) The frequency of CD4+CD25+FOXP3+ Treg cells in CD4+ T cells treated with NC or miR-181a inhibitor-transfected BMSC-derived exosomes analyzed by flow cytometry. . Data are the mean ± SD (n = 3 biological replicates).
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