Understanding of Immune Escape Mechanisms and Advances in Cancer Immunotherapy

Figure 4

Mechanism of combination immunotherapy in the treatment of immune “cold” tumors. (a) Microenvironment of an immune “cold” tumor before immunotherapy: less inflammatory cell infiltration and less lethal. (b) Changes of the TME after the combination of DCs tumor vaccine and ICIs inhibitor in the treatment of immune “cold” tumors: DCs tumor vaccine can enhance T cell infiltration, and PD-1/PD-L1 inhibitors can block the activation of PD-1/PD-L1 pathway and prevent T cell inactivation.