Solamargine Inhibits Prostate Cancer Cell Growth and Enhances the Therapeutic Efficacy of Docetaxel via Akt Signaling

Figure 2

Solamargine induced apoptosis and inhibited migration ability of CRPC cell lines. (a) and (b) Effect of solamargine on the migration ability of CRPC cells. PC3 and DU145 cells were wounded using a 200 μL micropipette tip and then incubated with or without solamargine. Cell images were taken at 0 and 24 h. The dotted lines show the area where the scratch wound was made. Scale bar: 100 μm. Quantitative data are presented as means ± SD of three independent experiments. (Values represent mean ± SD. and versus control). (c) PC3 cells were treated with different concentrations of solamargine for 24 h and then stained using Annexin V-FITC/PI. Cell apoptosis rates were determined using flow cytometry.

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