Solamargine Inhibits Prostate Cancer Cell Growth and Enhances the Therapeutic Efficacy of Docetaxel via Akt Signaling

<div>Solamargine impaired CRPC cell growth through Akt signaling. (a) PC3 and DU145 cells were treated with the indicated concentrations of dimethyl sulfoxide (DMSO) or solamargine (SM), and the protein levels of phosphorylated Akt (p-Akt) and total Akt were measured using Western blotting. (b) Constitutively active Akt plasmid was transfected into PC3 cells, and the expression level of p-Akt was detected using Western blotting. (c) Cell viability was evaluated by CCK-8 assay. (d) Solamargine-treated cells with or without Akt overexpression were examined by colony formation assay. (e) The numbers of colonies for each group were counted. 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Journal of Oncology

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Figure 3

Figure 3: Solamargine Inhibits Prostate Cancer Cell Growth and Enhances the Therapeutic Efficacy of Docetaxel via Akt Signaling 