Oncologic Outcomes of Renal Cell Carcinoma Patients Undergoing Radical Nephrectomy and Venous Thrombectomy: Prospective Follow-Up from a Single Center

Table 4

Univariate and multivariate Cox regression analysis of CSS.

	CSS
Covariate	Univariate analysis		Multivariate analysis
	HR (95% CI)	value	HR (95% CI)	value
Age	0.98 (0.97-1.01)	0.08
BMI	0.95 (0.90-0.99)	0.03	0.96 (0.90-1.01)	0.11
Thrombus level (/%)
I	Reference		Reference
II	1.44 (0.89-2.34)	0.14	1.27 (0.77-2.10)	0.35
III	1.29 (0.72-2.31)	0.39	0.87 (0.46-1.62)	0.65
Surgery (/%)
Open procedure	Reference		Reference
Laparoscopic procedure	0.67 (0.47-0.96)	0.03	0.80 (0.54-1.19)	0.27
Fuhrman grade (/%)
1-2	Reference		Reference
3	1.85 (1.16-2.97)	<0.01	2.10 (1.28-3.44)	0.003
4	4.72 (2.93-7.63)	<0.001	3.55 (2.09-6.03)	<0.001
Pathological type (/%)
Clear cell RCC	Reference		Reference
Papillary RCC	2.73 (1.73-4.31)	<0.001	2.95 (1.80-4.82)	<0.001
Other	3.63 (2.01-6.53)	<0.001	3.88 (2.03-7.41)	<0.001
Perinephric fat invasion (/%)
No	Reference		Reference
Yes	2.14 (1.49-3.08)	<0.001	1.53 (1.03-2.26)	0.04
Sarcomatoid differentiation (/%)
No	Reference		Reference
Yes	3.36 (2.18-5.16)	<0.001	2.85 (1.64-4.95)	<0.001
Metastasis (/%)
N0M0	Reference		Reference
N1-xM0	0.72 (0.40-1.31)	0.28	0.85 (0.46-1.56)	0.60
M1	1.88 (1.28-2.75)	0.001	1.76 (1.18-2.63)	0.006
Adjuvant therapy (/%)
No	Reference		Reference
Yes	0.67 (0.47-0.96)	0.03	0.63 (0.43-0.92)	0.02

CSS: cancer-specific survival; HR: hazard ratio; CI: confidence interval.