Single Nucleotide Polymorphism of Genes Associated with Metabolic Fatty Liver Disease

Table 3

Genotypes distribution in two groups and the risks of MAFLD.

Gene	tagSNPs	Cases (n = 282)		Controls (n = 282)		OR (95% CI)	value	Model	OR (95% CI)	value
		n	%	n	%
PNPLA3	rs738409 (G > C)
	GG	56	19.9	68	24.1	1.000		Dom	1.160 (0.824–1.615)	0.424
	GC	152	53.9	161	57.1	1.006 (0.713–1.447)	0.859	Rec	1.492 (1.080–2.066)	0.016
	CC	74	26.2	53	18.8	1.402 (1.026–2.239)	0.033	Add	1.232 (1.003–1.504)	0.046
MBOAT7	rs64173 (C > T)
	CC	53	18.8	64	22.7	1.000		Dom	1.018 (0.778–1.459)	0.848
	CT	159	56.4	167	59.2	1.003 (0.742–1.359)	0.979	Rec	1.398 (1.053–1.692)	0.032
	TT	70	24.8	51	18.1	1.299 (0.933–1.748)	0.040	Add	1.038 (0.856–1.259)	0.061
STAT3	rs744166 (G > A)
	GG	55	19.5	69	24.5	1.000		Dom	1.193 (0.957–1.491)	0.398
	GA	150	53.2	159	56.4	1.223 (0.842–1.573)	0.947	Rec	0.682 (0.372–1.195)	0.019
	AA	77	27.3	54	19.1	0.738 (0.469–1.201)	0.026	Add	1.004 (0.894–1.356)	0.059
TM6SF2	rs58542926 (C > T)
	CC	60	21.3	71	25.2	1.000		Dom	0.973 (0.765–1.320)	0.883
	CT	155	54.9	146	51.8	1.005 (0.782–1.392)	0.969	Rec	0.915 (0.657–1.280)	0.615
	TT	67	23.8	65	23.0	0.928 (0.631–1.336)	0.655	Add	0.952 (0.792–1.169)	0.699
GATAD2A	rs4808199 (G > A)
	AA	54	19.1	42	14.9	1.000		Dom	1.042 (0.769–1.415)	0.789
	AG	164	58.2	162	57.4	0.980 (0.719–1.364)	0.957	Rec	1.687 (0.734–3.897)	0.217
	GG	64	22.7	78	27.7	1.678 (0.719–3.883)	0.218	Add	1.088 (0.836–1.416)	0.536